The main objective of this project is to produce, by dielectric barrier discharge [DBD] plasma-assisted deposition at atmospheric pressure, a new generation of coatings containing nanoparticles [NPs] and enzybiotics with controllable antibacterial activity on medical textiles. NPs ions release and immobilized enzymes activity will be tune using a “sandwich” polymeric coating structure achieved by aerosol injection where a 1st antibacterial nanocomposite layer is covered by thicker 2nd layer in order to tune antibacterial effect. Various deposition parameters will be investigated including plasma power, NPs type and size, enzyme class, types of carrier gas, polymer, precursor and substrate. The main advantage of this method is its capability to produce, in a continuous process, coatings with strong bonding, high deposition rate and precise release of antibacterial agent.
The specific objectives of the project are:
1. The use of nanoparticles with antimicrobial activity and antibiofilm enzymes of proven efficacy.
2. Assembling of the colloidal sol-gel modified NPs with the selected enzymes eventually using spacers and/or stabilizers.
3. The atmospheric plasma assisted deposition of the bionanocomposite via controllable and tunable coatings barriers based on safe polymers onto commercial dressing for pressure injury and hernia meshes
4. Study the physico-chemical mechanism of hybrid nanoparticle deposition, the effectivity of nanocoating in antimicrobial activity and the precise control of plasma conditions.
5. Fully morphological, physico-chemical and thermo-mechanical characterization of the fabrics.
6. Test the antimicrobial properties and cytotoxicity of the new hybrid NPs-based medical textiles with special attention to pH imbalance.
Project Duration: July 2018 to July 2021
Eligible Cost: 225.826,45 €
European Union Funding: FEDER/FNR - 191.952,48€ e OE - 33,873,97 €
Intervention Region: Portugal